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4 edition of Potential cytoprotective role for UDP-glucuronosyltransferases (UGTs) in chemical carcinogenesis found in the catalog.

Potential cytoprotective role for UDP-glucuronosyltransferases (UGTs) in chemical carcinogenesis

Potential cytoprotective role for UDP-glucuronosyltransferases (UGTs) in chemical carcinogenesis

genotoxicity and cytotoxicity of benzo[a]pyrene and benzo[e]pyrene in UGT-deficient cultured rat skin fibroblasts.

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Published by National Library of Canada in Ottawa .
Written in English


Edition Notes

Thesis (M.Sc.)--University of Toronto, 1993.

SeriesCanadian theses = Thèses canadiennes
The Physical Object
FormatMicroform
Pagination2 microfiches : negative.
ID Numbers
Open LibraryOL15114240M
ISBN 100315872101
OCLC/WorldCa46534694

Jim Kaput, PhD, is the founder, President, and Chief Scientific Officer of NutraGenomics, Inc.. Raymond L. Rodriguez, PhD, is Professor of Molecular and Cellular Biology and Director of the Centerof Excellence in Nutritional Genomics at the University of California, Davis. Two UDP-glucuronosyltransferases, UGT1A9 and UGT2B7, have been shown to play an important role in the phase II metabolism of procarcinogenic metabolites of BaP. Because both enzymes are wellexpressed in digestive tract tissu es including colon, it is possible that genetic variations in either enzyme may play an important role in colon cancer risk.

Introduction. The UDP-glucuronosyltransferase (UGT) superfamily of enzymes catalyze the glucuronidation of various compounds, including endogenous compounds such as bilirubin and steroid hormones, as well as xenobiotics, including drugs and environmental carcinogens (1, 2, 3, 4).On the basis of structural as well as sequence homology, UGTs are classified into several families and . Lipoxygenases (LOXs) have been implicated as central players in ferroptosis, a recently characterized cell death modality associated with the accumulation of lipid hydroperoxides: the products of LOX catalysis. To provide insight on their role, human embryonic kidney cells were transfected to overexpress each of the human isoforms associated with disease, 5-LOX, pLOX, and LOX-1, which.

  Genetic polymorphism is referred to the discontinuous interspecies genetic variability among individuals having distinct alleles on a particular locus. Genetic polymorphism of genes encoding drug-metabolizing enzymes constitutes individual’s susceptibility to drugs, affirmed by having discrete allelic frequencies by the individual, strengthening the concept of precision medicine. Tamoxifen (TAM) is a selective estrogen receptor modulator that is widely used in the prevention and treatment of estrogen receptor-positive (ER +) breast use has significantly contributed to a decline in breast cancer mortality, since breast cancer patients treated with TAM for 5 years exhibit a % reduction in both the rate of disease recurrence after 10 years of patient.


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Potential cytoprotective role for UDP-glucuronosyltransferases (UGTs) in chemical carcinogenesis Download PDF EPUB FB2

Potential Genoprotective Role for UDP-Glucuronosyltransferases in Chemical Carcinogenesis: Initiation of Micronuclei by Benzo(a)pyrene and Benzo(e)pyrene in UDP-Glucuronosyltransferase-deficient Cultured Rat Skin Fibroblas& Diana S.

Vienneau, Umberto DeBoni, and Peter G. Wells2Cited by: These molecular mechanisms support the cytoprotective effects of OT against tissue damage present in many inflammatory diseases, including viral infections.

(4) Conclusions: The potential cytoprotective role of OT in the management of organ damage induced by COVID merits further research. Controlled clinical trials are : Gregorio Martínez-Sánchez, Adriana Schwartz, Vincenzo Di Donna.

Characterization of UDP-glucuronosyltransferase 2A1 (UGT2A1) variants and their potential role in tobacco carcinogenesis. Ryan T. Bushey, 1, 3 Gang Chen, 1, 4 Andrea S. Blevins-Primeau, 1, 3 Jacek Krzeminski, 2, 3 Shantu Amin, 2, 3 and Philip Lazarus 1, 3, 4 UDP-glucuronosyltransferases (UGTs) play an important role in the metabolism and Cited by:   The induction of cytoprotective autophagy requires the accumulation of glucose inside the hypoxic cells.

Glioma cells [] and endothelial cells treated with silibinin, a flavonoid extract, are protected from the glucose-induced damage via activation of autophagy [].The glucose is processed via glycolysis, yielding ATP for ATP-dependent detoxification of the stress stimuli [].Cited by: 2.

Title:Roles of UDP-Glucuronosyltransferases in Phytochemical Metabolism of Herbal Medicines and the Associated Herb-Drug Interactions VOLUME: 13 ISSUE: 5 Author(s):Li Li, Haihong Hu, Siyun Xu, Quan Zhou and Su Zeng Affiliation:Department of Pharmaceutical Analysis and Drug Metabolism, College of Pharmaceutical Sciences, Zhejiang University, Yuhangtang Road, Hangzhou.

Keywords:UDp Glucuronosyltransferases, UGT, anti inflammatory drugs, UDP. Role of Quality Management System (QMS) for Effective Regulatory Compliance Medicinal and Therapeutic Potential of Herbs and Plant Metabolites / Extracts Countering Viral Pathogens.

Parkinson's disease (PD) is a widespread neurodegenerative disorder characterized by the progressive loss of neurons. The accumulation of aggregated f. In vertebrates, the glucuronidation of small lipophilic agents is catalyzed by the endoplasmic reticulum UDP-glucuronosyltransferases (UGTs).

This metabolic pathway leads to the formation of water-soluble metabolites originating from normal dietary processes, cellular catabolism, or exposure to drugs and xenobiotics.

This classic detoxification process, which led to the discovery nearly We previously reported that serine (S47) phosphorylation of cytochrome c (Cytc) in the brain results in lower cytochrome c oxidase (COX) activity and caspase-3 activity in vitro.

We here analyze the effect of S47 modification in fibroblast cell lines stably expressing S47E phosphomimetic Cytc, unphosphorylated WT, or S47A Cytc. Our results show that S47E Cytc results in partial inhibition. Potential genoprotective role for UDP-glucuronosyltransferases in chemical carcinogenesis: initiation of micronuclei by benzo(a)pyrene and benzo(e)pyrene in UDP-glucuronosyltransferase-deficient cultured rat skin fibroblasts.

Introduction. Astrocytes have diverse and important functions in the pathology of cerebral gh astrocytes may be less susceptible than neurons to ischemic damage, astrocyte death is an important component of ischemia and has detrimental effects on neuronal survival and integrity.The susceptibility of astrocytes to ischemia depends on the brain region, and astrocytes.

Identification and characterization of human UDP-glucuronosyltransferases responsible for xanthotoxol glucuronidation. Xenobiotica: Vol. 48, No. 2, pp. UDP-glucuronosyltransferase: A liver enzyme essential to the disposal of bilirubin (the chemical that results from the normal breakdown of hemoglobin from red blood cells).

An abnormality of this enzyme (UDP-glucuronosyltransferase) results in a condition called Gilbert's disease in which there are mild elevations of bilirubin pigment in the blood. The elevated bilirubin pigment can sometimes. The book Heat Shock Protein-Based Therapies provides the most up-to-date review on new heat shock protein-based mechanisms used in the therapy and treatment of various human disorders and diseases, including cancer, muscular atrophy, neurodegenerative disorders (Alzheimer's Disease, Multiple Sclerosis) and infectious diseases (HIV, periodontal disease).

When AgNP was in the presence of CMC, no cytotoxic potential was verified, but only the genotoxic potential for AgNP dispersion having concentration of ppm. View full-text Article. UDP-Glucuronosyltransferases With Robert S. Foti, Upendra A. Argikar This chapter discusses basic Uridine diphosphate glucuronosyltransferases (UGT) enzymology, as well as the important role that UGTs play in drug metabolism, drug interactions and drug efficacy, and safety.

Vitamin C is an essential dietary nutrient for the biosynthesis of collagen and a co-factor in the biosynthesis of catecholamines, L-carnitine, cholesterol, amino acids, and some peptide hormones.

Inhibition of UDP‐glucuronosyltransferases (UGTs) can result in many undesired side effects. Diethylstilbestrol (DES), a synthetic oestrogen famous for its multiple toxicities, was once widely administered to women in high dosages and now still gains application in clinics.

aiming at disclosing new potential toxic mechanisms on the basis. A multifactorial disease cancer arises due to mutation in the gene encoding particular transcription factor or proteins. Globally cancer is one of the diseases which is responsible for maximum.

Mast cells (MCs) arise in situ from circulating stem cell factor (SCF)-dependent committed progenitors (PrMCs) and accumulate at sites of allergic mucosal inflammation.

We hypothe. Glucuronidation, catalyzed by the UDP-glucuronosyltransferases (UGT), is a major drug clearance mechanism in humans and other mammalian species. UGT reaction phenotyping involves determining which of the 19 known human UGTs are primarily responsible for glucuronidation of a particular drug.1 Article 2 Characterization of UDP-glucuronosyltransferases 3 and the potential contribution to nicotine tolerance in 4 Myzus persicae 5 Yiou Pan 1, Pengjun Xu 2, Xiaochun Zeng 1, Xuemei Liu 1 and Qingli Shang 1* 6 1 College of Plant Science, Jilin University, Changchun and PR China 7 2 Institute of Tobacco Research,Chinese Academy of Agricultural Sciences, Qingdao and PR.Uridine diphosphate (UDP)-glycosyltransferases (UGTs) are major phase II detoxification enzymes involved in glycosylation of lipophilic endobiotics and xenobiotics, including phytoalexins.

Nicotine, one of the most abundant secondary plant metabolites, is highly toxic to herbivorous insects. Plant-herbivore competition has been the major impetus for evolution of large superfamilies of UGTs and.